Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 2 Articles
The aim of the present study was designed to evaluate the antidepressant activities of Solanum violaceum using different animal models. Antidepressant activity was tested using various methods like locomotor activity, forced swim test and tail suspension test method. Pharmacological studies have been conducted to the ethanol extracts of Solanum violaceum leaves to evaluate their effects on the central nervous system (CNS). Animals treated with all three doses of ethanolic extract of leaves of Solanum violaceum (100, 200 and 400 mg/kg) witnessed an increased locomotor activity and a decrease in their immobility times in forced swim test and tail suspension tests which was significant when compared with control. Similarly, animals treated with imipramine (15 mg/kg), as expected showed a significant decrease in the immobility time....
Although diabetic hepatopathy is potentially less common, it may be appropriate for addition to the list of target organ conditions related to diabetes. This study was designed to evaluate the hepatoprotective properties of Clitoria ternatea L. leaves (CTL) in STZ-induced diabetes in rats. Wistar rats were made diabetic through single injection of STZ (75 mg/kg i.p.). The rats were randomly divided into four groups of 10 animals each: Group 1, healthy control; Group 2, nondiabetics treated with CTL administered orally (1.5%, w/v); Group 3, diabetics; Group 4, diabetics treated with CTL (1.5%, w/v) for 8 weeks. Serum biomarkers were assessed to determine hepatic injury. Malondialdehyde (MDA) and reduced glutathione (GSH) contents were measured to assess free radical activity in the liver tissue. Hepatic antioxidant activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) were also determined. The biochemical findings were matched with histopathological verifications. Liver MDA content and serum levels of ALT, AST, ALP and bilirubin in Group 3 significantly increased compared to Group 1 (P< 0.05) and significantly decreased in Group 4 compared to Group 3 (P< 0.05). Serum albumin level and GSH, SOD, CAT and GSH-Px contents of the liver in Group 3 were significantly decreased compared to Group 1 (P< 0.05) and were significantly increased in Group 4 compared to Group 3 (P< 0.05). Histopathologically, the changes were in the same direction with biochemical findings. This study proved the hepatoprotective activity of CTL in experimentally induced diabetic rats....
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